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HEY1 Polyclonal Antibody, Rockland™
SDP

Catalog No. 501992146
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100 μg
25 μL
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50-199-2146 25 μL
50-199-2145 100 μg
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Catalog No. 50-199-2146 Supplier Rockland Immunochemicals Supplier No. 600401HB5S
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Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human HEY1. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and 91.7% with dog and cattle.

Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.

Specifications

Antigen HEY1
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1.06 mg/mL
Conjugate Unconjugated
Formulation 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene HEY1
Gene Accession No. Q9WV93, Q9Y5J3
Gene Alias AI316788; AI414254; basic helix-loop-helix protein OAF1; basic helix-loop-helix transcription factor; BC8; bHLH protein Hesr-1/Hey1; BHLHB31; BOS_13914; cardiovascular basic helix-loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; Hairy-related transcription factor 1; Herp1; HERP2; hes related family bHLH transcription factor with YRPW motif 1; HESR1; HESR-1; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; hey1; hey1 protein; hHRT1; HRT1; HRT-1; id:ibd1292; LOC100344717; MGC1274; mHRT1; OAF1; zgc:110572
Gene Symbols HEY1
Host Species Rabbit
Quantity 25 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15213, 23462
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
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