HEY1 Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 600401HB5S

Catalog No. 50-199-2146

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against human HEY1. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse and 91.7% with dog and cattle.

Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.

Specifications

• Antigen: HEY1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HEY1
• Gene Alias: AI316788; AI414254; basic helix-loop-helix protein OAF1; basic helix-loop-helix transcription factor; BC8; bHLH protein Hesr-1/Hey1; BHLHB31; BOS_13914; cardiovascular basic helix-loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; Hairy-related transcription factor 1; Herp1; HERP2; hes related family bHLH transcription factor with YRPW motif 1; HESR1; HESR-1; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; hey1; hey1 protein; hHRT1; HRT1; HRT-1; id:ibd1292; LOC100344717; MGC1274; mHRT1; OAF1; zgc:110572
• Host Species: Rabbit
• Regulatory Status: RUO
• Gene ID (Entrez): 15213, 23462
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Western Blot
• Concentration: 1.06 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: Q9WV93, Q9Y5J3
• Gene Symbols: HEY1
• Quantity: 25 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody