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Invitrogen™ HFE2 Monoclonal Antibody (C5), Invitrogen™
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Catalog No. PIMA543773
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100 μL
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PIMA543773 100 μL
PIMA543774 20 μL
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Catalog No. PIMA543773 Supplier Invitrogen™ Supplier No. MA543773
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Description

Mouse Monoclonal Antibody

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HFE2
Applications Western Blot
Classification Monoclonal
Clone C5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene HFE2
Gene Accession No. Q6ZVN8, Q8N7M5
Gene Alias 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC
Gene Symbols HFE2
Host Species Mouse
Immunogen Lys234-Ser416 (Accession Q6ZVN8), with N-terminal His Tag.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 148738, 310681
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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