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Invitrogen™ HFE2 Polyclonal Antibody
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Catalog No. PIPA592412
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100 μL
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PIPA592412 100 μL
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Catalog No. PIPA592412 Supplier Invitrogen™ Supplier No. PA592412
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSPMALGANA TATRKLTIIF KNMQECIDQK VYQAEVDNLP VAFEDGSING GDRPGGSSLS IQTANPGNHV EIQAAYIGTT IIIRQTAGQL SFSIKVAEDV AMAFSAEQDL QLCVGGCPPS QRLSRSERNR RGAITIDTAR RLCKEGLPVE DAYFHSCVFD VLISGDPNFT VAAQAALEDA RAFLPDLEKL HLFPSD Positive Samples: HeLa, PC-3; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor.

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HFE2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene HFE2
Gene Accession No. Q6ZVN8, Q7TQ32, Q8N7M5
Gene Alias 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC
Gene Symbols HFE2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 148738, 310681, 69585
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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