Invitrogen™ HFE2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105717

Catalog No. PIPA5105717

Description

Antibody detects endogenous levels of total HFE2.

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Specifications

• Antigen: HFE2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HFE2
• Gene Alias: 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 148738, 310681, 69585
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6ZVN8, Q7TQ32, Q8N7M5
• Gene Symbols: HFE2
• Immunogen: A synthesized peptide derived from human HFE2(Accession Q6ZVN8), corresponding to amino acid residues L23-G73.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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