HFE2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 117581AP150UL

Catalog No. 50-172-7433

Description

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Specifications

• Antigen: HFE2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HFE2
• Gene Alias: Hemochromatosis type 2 protein, Hemojuvelin, HFE2, HFE2A, HJV, JH, RGM domain family member C, RGMC
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 148738, 310681, 69585
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q6ZVN8, Q7TQ32, Q8N7M5
• Gene Symbols: Hfe2
• Immunogen: HFE2 Fusion Protein Ag2354
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG