HFE2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5121914	Invitrogen™ PA5121914	20 μL
PIPA5121913	Invitrogen™ PA5121913	100 μL

Description

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Specifications

• Antigen: HFE2
• Applications: Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q6ZVN8
• Gene ID (Entrez): 148738
• Immunogen: Lys234-Ser416 (Accession Q6ZVN8), with N-terminal His Tag.
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Gene: HFE2

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Alias: 2310035L15Rik; 5230400G09Rik; AI414844; AI789733; DL M; DL-M; Fidgetin; haemojuvelin; HEMOCHROMATOSIS; hemochromatosis type 2 (juvenile); hemochromatosis type 2 (juvenile) (human homolog); hemochromatosis type 2 protein; Hemochromatosis type 2 protein homolog; hemojuvelin; Hemojuvelin BMP coreceptor; HFE 2; HFE2; HFE2A; HJV; JH; MGC23953; OTTHUMP00000059680; repulsive guidance molecule c; RGM C; RGM domain family member C; RGMC
• Gene Symbols: HFE2
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Product Type: Antibody