Invitrogen™ HGF Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA128023

Catalog No. PA128023

Description

Recommended positive controls: cervical lesions. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Specifications

• Antigen: HGF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hgf
• Gene Alias: C230052L06Rik; DFNB39; Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; F-TCF; hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Hepatopoeitin A; hepatopoeitin-A; HepatopoietinA; hepatopoietin-A; Hgf; HGF/SF; HGFB; HPTA; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; NK1; NK2; Scatter factor; scatter factor); SF; SF/HGF
• Host Species: Goat
• Purification Method: IgG fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 3082
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Neutralization, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 5% trehalose and no preservative
• Gene Accession No.: P14210
• Gene Symbols: Hgf
• Immunogen: Recombinant, human hepatocyte growth factor (rhHGF), expressed in the insect cell line Sf 21.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG