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Invitrogen™ HGS Polyclonal Antibody
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Catalog No. PIPA527491
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100 μL
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PIPA527491 100 μL
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Catalog No. PIPA527491 Supplier Invitrogen™ Supplier No. PA527491
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: H1299, HeLa, mouse brain, rat brain. Predicted reactivity: Mouse (85%), Rat (82%), Dog (92%), Rhesus Monkey (98%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HGS
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene HGS
Gene Accession No. O14964, Q99LI8, Q9JJ50
Gene Alias hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hgr; Hgs; Hrs; Hrs2; human growth factor-regulated tyrosine kinase substrate; protein pp110; SNAP-25-interacting protein Hrs-2; ZFYVE8
Gene Symbols HGS
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human HGS. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15239, 56084, 9146
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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