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Invitrogen™ HGS Polyclonal Antibody
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Catalog No. PIPA595931
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100 μL
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PIPA595931 100 μL
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Catalog No. PIPA595931 Supplier Invitrogen™ Supplier No. PA595931
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EQQKQTVQMR AQMPAFPLPY AQLQAMPAAG GVLYQPSGPA SFPSTFSPAG SVEGSPMHGV YMSQPAPAAG PYPSMPSTAA DPSMVSAYMY PAGATGAQAA PQAQAGPTAS PAYSSYQPTP TAGYQNVASQ APQSLPAISQ PPQSSTMGYM GSQSVSMGYQ PYNMQNLMTT LPSQDASLPP QQPYIAGQQP MYQQMAPSGG PPQQQPPVAQ QPQAQGPPAQ GSEAQLISFD; Positive Samples: THP-1, OVCAR3, MCF7, HepG2, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Cytoplasmic side, Early endosome membrane, Endosome, Peripheral membrane protein, multivesicular body membrane.

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HGS
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.11 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene HGS
Gene Accession No. O14964, Q99LI8, Q9JJ50
Gene Alias hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase substrate; HGNC:4897; Hgr; Hgs; Hrs; Hrs2; human growth factor-regulated tyrosine kinase substrate; protein pp110; SNAP-25-interacting protein Hrs-2; ZFYVE8
Gene Symbols HGS
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 548-777 of human HGS (NP_0047031).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15239, 56084, 9146
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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