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  5. Tocris Bioscience™ Hh-Ag1.5

Tocris Bioscience™ Hh-Ag1.5
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Catalog No. 78071
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78-071 1 mg
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Catalog No. 78-071 Supplier Tocris Bioscience™ Supplier No. 7807/1
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Description

Potent and high affinity Smo receptor agonist

Hh-Ag1.5 is a potent and high affinity Hedgehog (Hh) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay). It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells. Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.

Specifications

Chemical Name or Material 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS 612542-14-0
Quantity 1 mg
Target Smoothened
Molecular Formula C28H26ClF2N3OS
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