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Tocris Bioscience™ HHP 9
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Catalog No. 78285 Shop All R&D Systems Products
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78-285 5 mg
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Catalog No. 78-285 Supplier Tocris Bioscience™ Supplier No. 7828/5
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Description

BET bromodomain Degrader (PROTAC™); also potent Hedgehog pathway inhibitor

HHP 9 is a potent BET bromodomain Degrader (PROTAC™; DC50 values are 0.03 μM, 0.2 μM and 0.2 μM at BRD3, BRD2 and BRD4 respectively). BRD2, BRD3 and BRD4 are almost completely degraded by HHP 9 in vitro (after 27h incubation with 0.5 - 5 μM of HHP 9). Comprises a Hedgehog Pathway Inhibitor-1 ( HPI-1, Cat. No. 3839) coupled to a CRBN ligand. BET bromodomain degradation through HPP-9 results in long-acting Hh pathway inhibition.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Quantity 5 mg
Target Active Degraders
Molecular Formula C49H52N6O11
Purity 0.98
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