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HIF-1 alpha Antibody (HIF1A/84), Novus Biologicals™
SDP

Catalog No. NBP234248B Shop All R&D Systems Products
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0.2 mg
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NBP234248B 0.2 mg
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Catalog No. NBP234248B Supplier Novus Biologicals Supplier No. NBP2342480.2MG

Description

Mouse Monoclonal Antibody

HIF-1 alpha Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Functional Assay, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen HIF-1 alpha
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay
Classification Monoclonal
Clone HIF1A-84
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Functional
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. Q16665
Gene Alias ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, HIF-1 alpha, HIF1A, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcriptionfactor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1HIF1-ALPHA, PAS domain-containing protein 8, PASD8alpha subunit (basic helix-loop-helix transcriptionfactor)
Gene Symbols HIF1A
Host Species Mouse
Immunogen Recombinant human HIF1 alpha protein
Molecular Weight of Antigen 93 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Angiogenesis, Autophagy, Cancer, Cellular Markers, Chromatin Research, HIF Target Genes, Hypoxia, mTOR Pathway, Transcription Factors and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 3091
Test Specificity HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG2b κ
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