Invitrogen™ HIF-2 alpha Monoclonal Antibody (GT125)

Catalog No.	Quantity
PIMA527743	100 μL

Catalog No. PIMA527743 Supplier Invitrogen™ Supplier No. MA527743

Description

Mouse Monoclonal Antibody

Positive Control: HepG2 (1% O2 treatment for 24hr) Predicted Reactivity: Pig (83%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.

Specifications

• Antigen: HIF-2 alpha
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: GT125
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and no preservative
• Gene: EPAS1
• Gene Accession No.: P97481, Q99814, Q9JHS1
• Gene Alias: basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; endothelial PAS domain protein 1b; endothelial PAS domain-containing protein 1; endothelial PAS domain-containing protein 1b; EPAS; Epas1; EPAS-1; epas1b; Hif like protein; HIF1 alpha-like factor; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF-2 alpha; HIF2A; hif-2a; hif-2ab; HIF-2alpha; HIF-2-alpha; HIF2-alpha; HIF-related factor; HLF; HLF (HIF1alpha-like factor); HRF; hypoxia inducible factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; hypoxia-inducible factor 2-alpha; Member of PAS protein 2; mHLF; MOP2; PAS domain-containing protein 2; PASD2; wu:fq36f01
• Gene Symbols: EPAS1
• Host Species: Mouse
• Immunogen: Recombinant protein encompassing a sequence within the center region of human HIF2 alpha. The exact sequence is proprietary.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13819, 2034, 29452
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1