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Invitrogen™ HIF1AN Polyclonal Antibody
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Catalog No. APPA6593
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100 μL
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APPA6593 100 μL
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Catalog No. APPA6593 Supplier Invitrogen™ Supplier No. PA116593
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for HIF1AN (transient overexpression lysate), rat astrocytes, C6 and U251 gliomas.

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIF1AN
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Phosphate, tris citrate with 0.1% sodium azide; pH 7-8
Gene HIF1AN
Gene Accession No. Q8BLR9, Q9NWT6
Gene Alias 2310046M24Rik; A830014H24Rik; DKFZp762F1811; factor inhibiting HIF1; factor inhibiting HIF-1; FIH; FIH 1; FIH1; FIH-1; FLJ20615; FLJ22027; Hif1an; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia inducible factor 1 subunit alpha inhibitor; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Gene Symbols HIF1AN
Host Species Rabbit
Immunogen A synthetic peptide made to the C-terminal region of human Factor Inhibiting HIF-1 (between residues 300 and the C-terminus).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 309434, 319594, 55662
Target Species Human, Mouse, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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