Invitrogen™ HIF1AN Recombinant Rabbit Monoclonal Antibody (12F11)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA550010

Catalog No. FEMA550010

Description

HIF1AN Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow, ELISA

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [UniProt].

Specifications

• Antigen: HIF1AN
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9NWT6
• Gene Symbols: HIF1AN
• Immunogen: A synthesized peptide derived from human HIF1AN.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 12F11
• Conjugate: Unconjugated
• Gene: HIF1AN
• Gene Alias: 2310046M24Rik; A830014H24Rik; DKFZp762F1811; factor inhibiting HIF1; factor inhibiting HIF-1; FIH; FIH 1; FIH1; FIH-1; FLJ20615; FLJ22027; Hif1an; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia inducible factor 1 subunit alpha inhibitor; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55662
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid