HIF3A Monoclonal Antibody (OTI5B7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA800761

Catalog No. 50-167-8536

Description

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.

Specifications

• Antigen: HIF3A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9Y2N7
• Gene Symbols: HIF3A
• Immunogen: Human recombit protein fragment corresponding to amino acids 355-669 of human HIF3A produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5B7
• Conjugate: Unconjugated
• Gene: HIF3A
• Gene Alias: HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64344
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid