HIF3A Mouse anti-Human, Clone: OTI2F7, lyophilized, TrueMAB™

Catalog No.	Quantity
50-166-5292	100 μg

Catalog No. 50-166-5292 Supplier OriGene Supplier No. CF800737

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.

Specifications

• Antigen: HIF3A
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2F7
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: HIF3A
• Gene Accession No.: Q9Y2N7
• Gene Alias: HIF-3A, HIF3-alpha-1, IPAS, MOP7, PASD7, bHLHe17
• Gene Symbols: HIF3A
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 355-669 of human HIF3A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 64344
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1