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Invitrogen™ HIF3A Polyclonal Antibody
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Catalog No. PIPA536531
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100 μL
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PIPA536531 100 μL
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Catalog No. PIPA536531 Supplier Invitrogen™ Supplier No. PA536531
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 72 kDa. Purity is >95% by SDS-PAGE.

Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIF3A
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene HIF3A
Gene Accession No. Q0VBL6, Q9JHS2, Q9Y2N7
Gene Alias Basic-helix-loop-helix-PAS protein MOP7; BHLHE17; Class E basic helix-loop-helix protein 17; HIF-3 alpha; HIF3 alpha 1; HIF3A; HIF-3A; HIF-3-alpha; HIF3-alpha; HIF3-alpha-1; hypoxia inducible factor 3 alpha; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor 3, alpha subunit; hypoxia inducible factor 3a; hypoxia inducible factor three alpha; hypoxia-inducible factor 3 alpha; hypoxia-inducible factor 3-alpha; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; Mop7; Neonatal and embryonic PAS protein; NEPAS; PAS domain-containing protein 7; PASD7
Gene Symbols HIF3A
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 323-376 of human HIF-3 alpha.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53417, 64344, 64345
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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