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Invitrogen™ HIF3A Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA579362
Description
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Brain Tissue.
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (also designated Arnt 1), EPAS-1 (also designated HIF-2 alpha) and HIF-3 alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
Specifications
HIF3A | |
Polyclonal | |
Unconjugated | |
HIF3A | |
Basic-helix-loop-helix-PAS protein MOP7; BHLHE17; Class E basic helix-loop-helix protein 17; HIF-3 alpha; HIF3 alpha 1; HIF3A; HIF-3A; HIF-3-alpha; HIF3-alpha; HIF3-alpha-1; hypoxia inducible factor 3 alpha; hypoxia inducible factor 3 alpha subunit; hypoxia inducible factor 3, alpha subunit; hypoxia inducible factor 3a; hypoxia inducible factor three alpha; hypoxia-inducible factor 3 alpha; hypoxia-inducible factor 3-alpha; Inhibitory PAS domain protein; IPAS; Member of PAS protein 7; Mop7; Neonatal and embryonic PAS protein; NEPAS; PAS domain-containing protein 7; PASD7 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
64344, 64345 | |
-20°C | |
Lyophilized |
Western Blot | |
500 μg/mL | |
PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal | |
Q9JHS2, Q9Y2N7 | |
HIF3A | |
A synthetic peptide corresponding to a sequence at the C-terminus of human HIF3 (497-514aa DDDFQLNASEQLPRAYHR). | |
100 μg | |
Primary | |
Human, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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