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Invitrogen™ HIN-1 Monoclonal Antibody (3G5)
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Catalog No. PIMA522866
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100 μg
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Catalog No. Quantity
PIMA522866 100 μg
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Catalog No. PIMA522866 Supplier Invitrogen™ Supplier No. MA522866
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Description

Mouse Monoclonal Antibody

Peptide Sequence: MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL TVFG.

HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIN-1
Applications ELISA
Classification Monoclonal
Clone 3G5
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene SCGB3A1
Gene Accession No. Q96QR1
Gene Alias cytokine high in normal-1; cytokine HIN-1; High in normal 1; HIN1; HIN-1; LU105; pneumo secretory protein 2; PNSP2; PnSP-2; SCGB3A1; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867; UNQ629/PRO1245; Uteroglobin-related protein 2
Gene Symbols SCGB3A1
Host Species Mouse
Immunogen SCGB3A1 (AAH29176, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92304
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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