Invitrogen™ HIN-1 Monoclonal Antibody (3G5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522866

Catalog No. PIMA522866

Description

Peptide Sequence: MKLAALLGLC VALSCSSAAA FLVGSAKPVA QPVAALESAA EAGAGTLANP LGTLNPLKLL LSSLGIPVNH LIEGSQKCVA ELGPQAVGAV KALKALLGAL TVFG.

HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.

Specifications

• Antigen: HIN-1
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q96QR1
• Gene Symbols: SCGB3A1
• Immunogen: SCGB3A1 (AAH29176, 1 a.a. ~ 104 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA
• Clone: 3G5
• Conjugate: Unconjugated
• Gene: SCGB3A1
• Gene Alias: cytokine high in normal-1; cytokine HIN-1; High in normal 1; HIN1; HIN-1; LU105; pneumo secretory protein 2; PNSP2; PnSP-2; SCGB3A1; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867; UNQ629/PRO1245; Uteroglobin-related protein 2
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 92304
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid