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Invitrogen™ HIN-1 Monoclonal Antibody (410219)
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Catalog No. PIMA524147
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100 μg
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Catalog No. Quantity
PIMA524147 100 μg
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Catalog No. PIMA524147 Supplier Invitrogen™ Supplier No. MA524147
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Description

Mouse Monoclonal Antibody

In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse HIN-1 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIN-1
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 410219
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene SCGB3A1
Gene Accession No. Q96QR1
Gene Alias cytokine high in normal-1; cytokine HIN-1; High in normal 1; HIN1; HIN-1; LU105; pneumo secretory protein 2; PNSP2; PnSP-2; SCGB3A1; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867; UNQ629/PRO1245; Uteroglobin-related protein 2
Gene Symbols SCGB3A1
Host Species Mouse
Immunogen E. coli-derived recombinant human HIN-1/SCGB3A1 Phe21-Gly104.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92304
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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