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Invitrogen™ HINT1 Polyclonal Antibody
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Catalog No. PIPA520613
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100 μg
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Catalog No. Quantity
PIPA520613 100 μg
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Catalog No. PIPA520613 Supplier Invitrogen™ Supplier No. PA520613
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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-20613 can be used with blocking peptide PEP-0733.

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HINT1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Hint1
Gene Accession No. P49773, P62959, P70349
Gene Alias 17 kDa inhibitor of protein kinase C; AA673479; Adenosine 5'-monophosphoramidase; FLJ30414; FLJ32340; HINT; Hint1; histidine triad nucleotide binding protein 1; histidine triad nucleotide-binding protein 1; Ipk1; NMAN; PKC inhibitor/ interacting protein; Pkci; PKCI1; PKCI-1; Prkci; PRKCNH1; protein kinase C inhibitor 1; protein kinase C, iota; protein kinase C-interacting protein 1
Gene Symbols Hint1
Host Species Rabbit
Immunogen A 17 amino acid peptide near the center of the human HINT1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15254, 3094, 690660
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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