HINT1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6535	Proteintech Group Inc 107171AP150UL	150 μL

Description

This antibody is specific to HINT1.

Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5′-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.

Specifications

• Antigen: HINT1
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P49773, P62959, P70349
• Gene ID (Entrez): 15254, 3094, 690660
• Immunogen: HINT1 Fusion Protein Ag1142
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: HINT1

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: HINT, HINT1, PKCI 1, PKCI1, PRKCNH1, Protein kinase C inhibitor 1
• Gene Symbols: Hint1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody