Invitrogen™ HIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109238

Catalog No. PIPA5109238

Description

Positive Control: Mouse testis tissue lysate, Mouse spinal cord tissue lysate, A549, PC-3M, SH-SY5Y, human colon cancer tissue, mouse brain tissue, mouse fallopian tubes tissue.

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

Specifications

• Antigen: HIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HIP1
• Gene Alias: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP I; hip1; HIP-1; HIP-I; huntingtin interacting protein 1; huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 215114, 3092
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O00291, Q8VD75
• Gene Symbols: HIP1
• Immunogen: Synthetic peptide within mouse Hip1 aa 980-1,029.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG