Invitrogen™ HIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553068

Catalog No. PIPA553068

Description

Immunogen sequence: NFLRASALSE HISPVVVIPA EASSPDSEPV LEKDDLMDMD ASQQNLFDNK FDDIFGSSFS SDPFNFNSQN GVNKDEKDHL IERLYREISG LKAQLENMKT ESQRVVLQLK GHVSELEADL AEQQHLRQQA ADDCEFLRAE LDELRRQRED Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.

Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.

Specifications

• Antigen: HIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HIP1
• Gene Alias: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP I; hip1; HIP-1; HIP-I; huntingtin interacting protein 1; huntingtin-interacting protein 1; Huntingtin-interacting protein I; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192154, 215114, 3092
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O00291, Q8VD75
• Gene Symbols: HIP1
• Immunogen: Recombinant protein corresponding to Human HIP1. Recombinant protein control fragment (Product #RP-90751).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG