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Invitrogen™ HIP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583038

Catalog No. PIPA583038


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Description

Description

Immunogen sequence: VTGAICLDIL KDQWAAAMTL RTVLLSLQAL LAAAEPDDPQ DAVVANQYKQ NPEMFKQTAR LWAHVYAGAP VSSPEYTKKI ENLCAMGFDR NAVIVALSSK SWDVETATEL.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HIP2
Polyclonal
Unconjugated
UBE2K
AW492011; D5Ertd601e; DKFZp564C1216; DKFZp686J24237; E2 ubiquitin-conjugating enzyme K; E2(25K); E2-25k; HIP2; HIP-2; huntingtin interacting protein 2; huntingtin-interacting protein 2; HYPG; LIG; UBC1; UBE2K; Ubiquitin carrier protein; ubiquitin conjugating enzyme E2 K; ubiquitin conjugating enzyme E2K; ubiquitin-conjugating enzyme E2 K; Ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase
Rabbit
Antigen affinity chromatography
RUO
3093
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
0.3 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P61086
UBE2K
Recombinant protein corresponding to Human UBE2K. Recombinant protein control fragment (Product #RP-102065).
100 μL
Primary
Human
Antibody
IgG
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