Invitrogen™ HIP55 Polyclonal Antibody

Catalog No.	Quantity
PIPA531207	100 μL

Catalog No. PIPA531207 Supplier Invitrogen™ Supplier No. PA531207

Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji. Predicted reactivity: Mouse (95%), Rat (96%), Xenopus laevis (86%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Specifications

• Antigen: HIP55
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.99 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene: DBNL
• Gene Accession No.: Q9UJU6
• Gene Alias: Abp1; Actin-binding protein 1; cervical mucin-associated protein; Cervical SH3P7; CMAP; DBNL; dbnl {ECO:0000312; drebrin F; drebrin like; drebrin-F; drebrin-like; drebrin-like protein; EMBL:AAH72483.1}; HIP55; HIP-55; HPK1-interacting protein of 55 kDa; mAbp1; PP5423; SH3 domain-containing protein 7; Sh3p7; src homology 3 domain-containing protein HIP-55
• Gene Symbols: DBNL
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human HIP55. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 28988
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG