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Invitrogen™ HIPK2 Polyclonal Antibody
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Catalog No. PIPA5110733
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100 μL
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PIPA5110733 100 μL
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Catalog No. PIPA5110733 Supplier Invitrogen™ Supplier No. PA5110733
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QVFSPHTLQS SAFCSVKKLK IEPSSNWDMT GYGSHSKVYS QSKNIPLSQP ATTTVSTSLP VPNPSLPYEQ TIVFPGSTGH IVVTSASSTS VTGQVLGGPH NLMRRSTVSL LDTYQKCGLK RKSEEIENTS SVQIIEEHPP Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.

The HIPK2 gene encodes a member of the homeodomain-interacting protein kinase family, specifically a serine/threonine nuclear protein kinase. HIPK2 plays versatile roles in cellular processes, including transcription regulation, cell proliferation, differentiation, and apoptosis. It interacts with various transcription factors and proteins, contributing significantly to the modulation of gene expression. Notably, HIPK2 is involved in the activation of the tumor suppressor protein p53, with p53-dependent pro-apoptotic activity, positioning HIPK2 as a potential tumor suppressor gene. Recent studies highlight its downregulation in multiple tumor types and its emerging role in cancer biology and therapy. Its expression is subject to quality control mechanisms, including autophosphorylation at serine and threonine sites. Structurally, the crystal structure of HIPK2 reveals unique conformational attributes that contribute to its functionality in different signaling pathways. HIPK2's influence extends to physiological processes, such as fibrosis and central nervous system regulation, indicating its broad biological significance and potential therapeutic applications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIPK2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HIPK2
Gene Accession No. Q9H2X6
Gene Alias 1110014O20Rik; B230339E18Rik; cb1009; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; si:dkey-16j24.2; si:dkey-239k7.1; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank; wu:fk56d12
Gene Symbols HIPK2
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human HIPK2. Recombinant protein control fragment (Product #RP-102530).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28996
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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