HIPPI Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5106283

Catalog No. PIPA5106283

Description

Antibody detects endogenous levels of total IFT57.

HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Specifications

• Antigen: HIPPI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IFT57
• Gene Alias: 4833420A15Rik; dermal papilla-derived protein 8; DERP8; Esrrbl1; estrogen-related receptor beta like 1; estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; Hippi; huntingtin interacting protein-1 interacting protein; huntingtin-interacting protein-1 protein interactor; IFT57; intraflagellar transport 57; intraflagellar transport 57 homolog; intraflagellar transport protein 57 homolog; MHS4R2; Vestrogen-related receptor beta like 1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 303968, 478553, 55081, 73916
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8BXG3, Q9NWB7
• Gene Symbols: IFT57
• Immunogen: A synthesized peptide derived from human IFT57(Accession Q9NWB7), corresponding to amino acid residues F84-S134.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov