Invitrogen™ HIRA Recombinant Rabbit Monoclonal Antibody (6Q7Y6)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542899

Catalog No. PIMA542899

Description

Positive test controls include: HeLa, 293T. Immunogen sequence: PSVLTTPSKI EPMKAFDSRF TERSKATPGA PALTSMTPTA VERLKEQNLV KELRPRDLLE SSSDSDEKVP LAKASSLSKR KLELEVETVE KKKKGRPRKD SRLMPVSLSV QSPAALTAEK EAMCLS.

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Specifications

• Antigen: HIRA
• Classification: Recombinant Monoclonal
• Concentration: 1.5 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P54198
• Gene Symbols: HIRA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 550-675 of human HIRA (P54198).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 6Q7Y6
• Conjugate: Unconjugated
• Gene: HIRA
• Gene Alias: AA138857; D16Ertd95e; DGCR1; DiGeorge critical region gene 1; Gm15797; HIR; HIR histone cell cycle regulation defective homolog A; Hira; histone cell cycle regulation defective homolog A; histone cell cycle regulation defective homolog A (S. cerevisiae); histone cell cycle regulator; N28177; OTTMUSG00000026264; Protein HIRA; TUP1; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; TUPLE1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7290
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov