Invitrogen™ HIST1H2BA Monoclonal Antibody (OTI1C9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526966

Catalog No. PIMA526966

Description

HIST1H2BA Monoclonal Antibody for Western Blot, IHC (P)

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Specifications

• Antigen: HIST1H2BA
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96A08
• Gene Symbols: H2bc1
• Immunogen: Human recombinant protein fragment corresponding to amino acids 2-127 of HIST1H2BA produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C9
• Conjugate: Unconjugated
• Gene: H2bc1
• Gene Alias: bA317E16.3; H2B histone family, member U, (testis-specific); H2BFU; HIST1H2BA; histone 1, H2ba; histone cluster 1, H2ba; histone H2B type 1-A; Histone H2B, testis; STBP; testis-specific histone H2B; TH2B; TSH2B; TSH2B.1; TSH2B1
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 255626
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid