Invitrogen™ Histone H2B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143705

Catalog No. PIPA5143705

Description

The antibody detects a 15 kDa* protein corresponding to the molecular mass of Histone H2B on SDS-PAGE immunoblots of human A431, Jurkat, HeLa, mouse C2C12, rat PC12, and A7r5 cells. The antibody also shows nuclear labeling in immunocytochemistry of methanol/acetone fixed cells.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The nucleosomes wrap further and compact DNA into chromotin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones play a central role in transciption regulation, DNA repair, DNA replication, and chromosomal stability. H2B has a broad antibacterial activity.

Specifications

• Antigen: Histone H2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H2BW2
• Gene Alias: 2610022J01Rik; Acetyl-Histone H2; AV127319; bA317E16.3; CG17949; CG17949-PA; CG33868; CG33868-PA; CG33870; CG33870-PA; CG33872; CG33872-PA; CG33874; CG33874-PA; CG33876; CG33876-PA; CG33878; CG33878-PA; CG33880; CG33880-PA; CG33882; CG33882-PA; CG33884; CG33884-PA; CG33886; CG33886-PA; CG33888; CG33888-PA; CG33890; CG33890-PA; CG33892; CG33892-PA; CG33894; CG33894-PA; CG33896; CG33896-PA; CG33898; CG33898-PA; CG33900; CG33900-PA; CG33902; CG33902-PA; CG33904; CG33904-PA; CG33906; CG33906-PA; CG33908; CG33908-PA; CG33910; CG33910-PA; dJ160A22.3; dJ193B12.2; dJ221C16.3; dJ221C16.6; dJ221C16.8; dJ97D16.4; Dmel\CG17949; Dmel\CG33868; Dmel\CG33870; Dmel\CG33872; Dmel\CG33874; Dmel\CG33876; Dmel\CG33878; Dmel\CG33880; Dmel\CG33882; Dmel\CG33884; Dmel\CG33886; Dmel\CG33888; Dmel\CG33890; Dmel\CG33892; Dmel\CG33894; Dmel\CG33896; Dmel\CG33898; Dmel\CG33900; Dmel\CG33902; Dmel\CG33904; Dmel\CG33906; Dmel\CG33908; Dmel\CG33910; Dmel_CG17949; Dmel_CG33868; Dmel_CG33870; Dmel_CG33872; Dmel_CG33874; Dmel_CG33876; Dmel_CG33878; Dmel_CG33880; Dmel_CG33882; Dmel_CG33884; Dmel_CG33886; Dmel_CG33888; Dmel_CG33890; Dmel_CG33892; Dmel_CG33894; Dmel_CG33896; Dmel_CG33898; Dmel_CG33900; Dmel_CG33902; Dmel_CG33904; Dmel_CG33906; Dmel_CG33908; Dmel_CG33910; fj05g08; GL105; H2B; H2B 291A; H2B 291B; H2b 613; H2B clustered histone 1; H2B clustered histone 15; H2B clustered histone 17; H2B clustered histone 19; H2B clustered histone 2, pseudogene; H2B clustered histone 21; H2B clustered histone 5; H2B clustered histone 8; H2B GL105 antibody; H2B histone family member M; H2B histone family member W testis-specific; H2B histone family member W, testis specific; H2B histone family, member A; H2B histone family, member B; H2B histone family, member C; H2B histone family, member D; H2B histone family, member E; H2B histone family, member F; H2B histone family, member J; H2B histone family, member K; H2B histone family, member L; H2B histone family, member M; H2B histone family, member N; H2B histone family, member Q; H2B histone family, member R; H2B histone family, member S; H2B histone family, member T; H2B histone family, member U, (testis-specific); H2B histone family, member W, testis-specific; H2B I; H2B II; H2B III; H2B IV; H2B K; H2B type 12; H2B VI; H2B VII; H2B.1; H2B.1 antibody; H2B.1A; H2B.1B; H2B.2; H2B.U histone 1; H2B.W histone 1; H2B/a; H2B/b; H2B/c; H2B/d; H2B/e; H2B/f; H2B/g; H2B/h; H2B/I; H2B/j; H2B/k; H2B/l; H2B/n; H2B/o; H2B/q; H2B/r; H2B/S; H2B/t; H2B1; H2B1.1; H2B1.2; h2B-143; H2B2; H2b-221; H2b-291b; H2b-613; H2Bb; H2BC1; H2BC10; H2BC15; H2BC17; H2BC19; H2BC21; H2BC2P; H2BC4; H2BC5; H2BC6; H2BC7; H2BC8; H2b-f; H2BFA; H2BFAiii; H2BFB; H2BFC; H2BFD; H2BFE; H2BFF; H2BFG; H2BFH; H2BFJ; H2BFK; H2BFL; H2BFM; H2BFN; H2BFO; H2BFQ; h2bfr; H2BFS; H2BFT; H2BFU; H2BFWT; H2BGL105; H2B-I; H2B-II; H2B-III; H2B-IV; H2BJ; H2b-j; H2BK; H2BK12ac; H2BK15ac; H2BK5ac; H2b-l; H2b-n; H2BQ; H2BS14; H2BS14p; H2BU1; H2B-VI; H2B-VII; H2BW1; HIRA-interacting protein 1; HIRA-interacting protein 2; HIRIP1; HIRIP2; His2B; His2B:CG17949; His2B:CG17949-PA; His2B:CG33868; His2B:CG33868-PA; His2B:CG33870; His2B:CG33870-PA; His2B:CG33872; His2B:CG33872-PA; His2B:CG33874; His2B:CG33874-PA; His2B:CG33876; His2B:CG33876-PA; His2B:CG33878; His2B:CG33878-PA; His2B:CG33880; His2B:CG33880-PA; His2B:CG33882; His2B:CG33882-PA; His2B:CG33884; His2B:CG33884-PA; His2B:CG33886; His2B:CG33886-PA; His2B:CG33888; His2B:CG33888-PA; His2B:CG33890; His2B:CG33890-PA; His2B:CG33892; His2B:CG33892-PA; His2B:CG33894; His2B:CG33894-PA; His2B:CG33896; His2B:CG33896-PA; His2B:CG33898; His2B:CG33898-PA; His2B:CG33900; His2B:CG33900-PA; His2B:CG33902; His2B:CG33902-PA; His2B:CG33904; His2B:CG33904-PA; His2B:CG33906; His2B:CG33906-PA; His2B:CG33908; His2B:CG33908-PA; His2B:CG33910; His2B:CG33910-PA; HIST1H2B7; HIST1H2B7L3; hist1h2ba; HIST1H2BB; HIST1H2BB antibody; Hist1h2bc; HIST1H2BD; HIST1H2BE; HIST1H2BF; HIST1H2BG; Hist1h2bh; HIST1H2BI; Hist1h2bj; hist1h2bj.L; hist1h2bj.S; HIST1H2BK; HIST1H2BL
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 102724334, 114483833, 128312, 158983, 24829, 255626, 286436, 291157, 3017, 3018, 319177, 319178, 319181, 319182, 319183, 319184, 319186, 319190, 361247, 440689, 68024, 680312, 691488, 8339, 8340, 8341, 8342, 8345, 8346, 8347, 8348, 8349, 85236, 8970
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
• Gene Accession No.: A0A2R8Y619, O60814, P06899, P0C1H6, P10854, P23527, P33778, P57053, P58876, P62807, P70696, Q00729, Q16778, Q5QNW6, Q64475, Q64478, Q64524, Q6ZWY9, Q7Z2G1, Q8CGP1, Q8N257, Q93079, Q96A08, Q99877, Q99879, Q99880
• Gene Symbols: H2B, H2bc1, H2BC10, H2BC11, H2BC12, H2BC13, H2BC14, H2BC15, H2BC17, H2bc18, H2BC21, H2BC3, H2BC4, H2BC5, H2BC8, H2BC9, H2BE1, H2BU1, H2BW1, H2BW2, HIST1H2BA, HIST1H2BD, HIST1H2BJ, HIST1H2BM, HIST1H2BO, LOC102724334
• Immunogen: Histone H2B synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminus of human histone H2B. This sequence is well conserved in rat, mouse, fish, and drosophila histone H2B, and has low homology to other histone family members.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG