Invitrogen™ Histone H3.3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587720

Catalog No. PIPA587720

Description

Immunogen sequence: MARTKQTARK STGGKAPRKQ LATKAARKSA PSTGGVKKPH RYRPGTVALR EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA; Positive Samples: A-549, SW620, U-87MG, MCF7, LO2; Cellular Location: Chromosome, Nucleus.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

Specifications

• Antigen: Histone H3.3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: H3-3A
• Gene Alias: 9430068D06Rik; CG5825; CG5825-PA; CG5825-PC; CG5825-PD; CG8989; dH3.3A; Dmel\CG5825; Dmel_CG5825; family 3B (H3.3B); H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3.3; H3.3 histone A; H3.3 histone B; H3.3A; H3.3A/B; H3.3B; H3.4; H3.A; H3.B; H3/g; H3-3A; H3-3B; H3B; H3F3; H3F3A; H3F3A protein; H3F3B; H3FT; H3-IX; H3L-like histone; H3t; H3-X; His3.3; His3.3A; His-3.3A; His3.3A-PA; His3.3A-PC; His3.3A-PD; His3.3B; histone; Histone cluster 3; Histone H3; histone H3 class II; Histone H3.3; histone H3.3A; Histone H3.3B; histone H3.3-like protein; MGC126886; MGC126888; PH3; PP781; similar to H3 histone, family 3A; unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3020, 3021
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.28 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P84243
• Gene Symbols: H3-3A, H3-3B
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human H3F3B (NP_0020981).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov