Histone H3S10ph Monoclonal Antibody (6G8B7), Active Motif™

Catalog No.	Quantity
50-199-3560	100 μg
50-199-3561	10 μg

Catalog No. 50-199-3560 Supplier Active Motif Supplier No. 61623

Description

Rat Monoclonal Antibody

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Specifications

• Antigen: Histone H3S10ph
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 6G8B7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Host Species: Rat
• Immunogen: This antibody was raised against a peptide corresponding to amino acids 1-19 including phospho-serine 10 of human Histone H3.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a