Histone H3S10ph Mouse anti-Human, Active Motif™

Mouse Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3850	Active Motif 91132	10 μg
50-199-3849	Active Motif 91131	100 μg

Description

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

Specifications

• Antigen: Histone H3S10ph
• Applications: Dot Blot, Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Immunogen: This antibody was raised against a peptide containing phospho-serine 10 of Histone H3.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles

• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody