HIV1 nef Monoclonal Antibody (2H12), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA171505

Catalog No. MA171505

Description

This antibody reacts with HIV-1 Nef, B and C subtypes, BRU, IIIB, and HAN strains. This clone may also be referred to as 2H12 (01-007).

HIV-1 Nef is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of receptor protein of the cell surface such as CD 4 and MH4, important for AIDS virus infection.

Specifications

• Antigen: HIV1 nef
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 2H12
• Conjugate: Unconjugated
• Gene Alias: HIV-1 Nef
• Immunogen: Recombinant Nef protein of HIV-1 BRU purified from E. coli
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid