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Invitrogen™ HIV1 (Virion infectivity factor) Polyclonal Antibody
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Catalog No. PIPA5106457
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100 μL
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PIPA5106457 100 μL
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Catalog No. PIPA5106457 Supplier Invitrogen™ Supplier No. PA5106457
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Virion infectivity factor.

The HIV-1 viral infectivity factor (Vif) is a crucial protein for the efficient replication of the virus, particularly in non-permissive cells such as lymphocytes and macrophages. Vif is a basic phosphoprotein with a molecular weight of approximately 23,000 Daltons. Its primary function is to counteract the host cellular antiviral protein APOBEC3G, which induces hypermutations in the viral DNA, thereby inhibiting viral replication. Vif achieves this by targeting APOBEC3G for ubiquitination and subsequent degradation, thus preventing it from incorporating into new virions. Structurally, Vif interacts with the cellular ubiquitin-proteasome machinery to facilitate the degradation of APOBEC3G. This interaction is essential for Vif's role in viral replication and immune evasion. Additionally, Vif has been shown to suppress the production of type I interferon by targeting the immune signaling molecule STING, further aiding in immune evasion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HIV1 (Virion infectivity factor)
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Alias HIV-1
Host Species Rabbit
Immunogen A synthesized peptide derived from human immunodeficiency virus 1 Virion infectivity factor(Accession Q7SPT8), corresponding to amino acid residues G126-Q146.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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