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Tocris Bioscience™ HJC 0416 hydrochloride
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Catalog No. 611010
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10 mg
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Catalog No. Quantity
61-101-0 10 mg
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Catalog No. 61-101-0 Supplier Tocris Bioscience™ Supplier No. 6110/10
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Description

STAT3 inhibitor

HJC 0416 hydrochloride is a STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.

Specifications

Chemical Name or Material 2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)benzamide hydrochloride
Quantity 10 mg
Target STAT Inhibitors
Molecular Formula C18H17ClN2O4S.HCl
Formula Weight 1818
Purity 97%
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