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HK2 Recombinant Rabbit Monoclonal Antibody (2H8L6), Invitrogen™

Catalog No. PI700422
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100 μg
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PI700422 100 μg
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Catalog No. PI700422 Supplier Thermo Scientific Supplier No. 700422
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with bovine, mouse and rat based on sequence homology. Intact IgG appears on a non-reducing gel as ∽150 kDa band and upon reduction generating a ∽25 kDa light chain band and a ∽50 kDa heavy chain. Recombit rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombit rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase activity is involved in the first step in several metabolic pathways including phosphorylation of glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase 2 is the predomit hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HK2
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Recombinant Monoclonal
Clone 2H8L6
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene HK2
Gene Accession No. P52789
Gene Alias HK II, hexokinase type II, hexokinase-2, hexokinase-2 muscle, muscle form hexokinase
Gene Symbols HK2
Host Species Rabbit
Immunogen A recombit protein corresponding to amino acids 325-444.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3099
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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