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Invitrogen™ HKDC1 Polyclonal Antibody

Catalog No. PIPA535894
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100 μL
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PIPA535894 100 μL
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Catalog No. PIPA535894 Supplier Invitrogen™ Supplier No. PA535894
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T. Predicted reactivity: Mouse (92%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The epidermal growth factor receptor (HKDC1; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). HKDC1 exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). HKDC1 and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to HKDC1 overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of HKDC1, called HKDC1vIII is often observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HKDC1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.45 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Hkdc1
Gene Accession No. Q2TB90, Q91W97
Gene Alias BC016235; hexokinase 1-like; hexokinase domain containing 1; hexokinase domain-containing protein 1; Hexokinase HKDC1; Hkdc1; LOC100364027; putative hexokinase HKDC1
Gene Symbols Hkdc1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human HKDC1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216019, 80201
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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