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Invitrogen™ HKDC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109286

Catalog No. PIPA5109286


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Description

Description

Positive Control: LOVO, MCF-7, SiHa, rat kidney tissue, mouse brain tissue.

The epidermal growth factor receptor (HKDC1; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). HKDC1 exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). HKDC1 and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to HKDC1 overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of HKDC1, called HKDC1vIII is often observed.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HKDC1
Polyclonal
Unconjugated
Hkdc1
BC016235; hexokinase 1-like; hexokinase domain containing 1; hexokinase domain-containing protein 1; Hexokinase HKDC1; Hkdc1; LOC100364027; putative hexokinase HKDC1
Rabbit
Affinity Chromatography
RUO
80201
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Q2TB90
Hkdc1
Recombinant protein within Human HKDC1 aa 266-462.
100 μL
Primary
Human
Antibody
IgG
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