Invitrogen™ HLA-DMA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103886

Catalog No. PIPA5103886

Description

Antibody detects endogenous levels of total HLA-DMA.

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DMA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HLA-DMA
• Gene Alias: class II histocompatibility antigen, M alpha chain; D6S222E; DAAP-27A1.5; DMA; HLA class II histocompatibility antigen, DM alpha chain; HLADM; HLA-DMA; major histocompatibility complex, class II, DM alpha; MHC class II antigen DMA; really interesting new gene 6 protein; RING6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3108
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P28067
• Gene Symbols: HLA-DMA
• Immunogen: A synthesized peptide derived from human HLA-DMA(Accession P28067), corresponding to amino acid residues M34-E84.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov