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Invitrogen™ HLA-DOA Polyclonal Antibody
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Catalog No. PIPA5109820
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100 μL
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PIPA5109820 100 μL
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Catalog No. PIPA5109820 Supplier Invitrogen™ Supplier No. PA5109820
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: TKADHMGSYG PAFYQSYGAS GQFTHEFDEE QLFSVDLKKS EAVWRLPEFG DFARFDPQGG LAGIAAIKAH LDILVERSNR SRAINVPPRV TVLPKSRVEL GQPNILICIV DNIFPPVINI TWLRNGQTVT EGVAQTSFYS QPDHLFRKFH YLPFVPSAED VYDCQVEHWG LDAPLLRHWE LQVPIPPPDA ME.

Reacts with HLA-DO, a heterodimer formed by DNalpha and DObeta subunits in B cells. DNalpha and DObeta are the products of the non-classical class II genes, HLA-DNA and HLA-DOB, respectively. DO forms tight complexes with DM in the endoplasmic reticulum and is thereby sorted to lysosomal vesicles during antigen processing and presentation. It is tightly associated with DM and it is selectively expressed on antigen-presenting cells, such as B cells, dendritic cells and thymic epithelial cells. DO can enhance the efficiency of peptide loading and has been found to stabilize DM at low pH, preserving its chaperon activity. DO-DM complexes are more efficient than DM in protecting empty DR molecules. Reports describe DO as a co-chaperone of DM. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HLA-DOA
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.14 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene HLA-DOA
Gene Accession No. P06340
Gene Alias HLA class II histocompatibility antigen, DO alpha chain; HLA-D0-alpha; HLA-DNA; HLA-DOA; HLADZ; HLA-DZA; lymphocyte antigen; major histocompatibility complex, class II, DN alpha; major histocompatibility complex, class II, DO alpha; MHC class II antigen DOA; MHC DN-alpha; MHC DZ alpha
Gene Symbols HLA-DOA
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-217 of human HLA-DOA (NP_002110.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3111
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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