Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA553095

Invitrogen™ HLA-DOB Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA553095
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA553095 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA553095 Supplier Invitrogen™ Supplier No. PA553095
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Immunogen sequence: KADCYFTNGT EKVQFVVRFI FNLEEYVRFD SDVGMFVALI KLGQPDAEQW NSRLDLLERS RQAVDGVCRH NYRLGAPFTV GRKVQPEVTV YPERTPLLHQ HNLLHCSVTG FYPGDIKIKW FLNGQEERAG VMSTGPIRNG D Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.

Peptide (antigen) binding to major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II-Ig dimers and by the activity of MHC molecules HLA-DM and -DO. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HLA-DOB
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HLA-DOB
Gene Accession No. P13765
Gene Alias DOB; HLA class II histocompatibility antigen, DO beta chain; HLA-DO beta; HLA-DOB; major histocompatibility complex, class II, DO beta; MHC class II antigen DOB
Gene Symbols HLA-DOB
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human HLA-DOB. Recombinant protein control fragment (Product #RP-90438).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3112
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.