HLA-DPB1 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA589566	100 μL

Catalog No. PIPA589566 Supplier Thermo Scientific Supplier No. PA589566

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RATPENYLFQ GRQECYAFNG TQRFLERYIY NREEFARFDS DVGEFRAVTE LGRPAAEYWN SQKDILEEKR AVPDRMCRHN YELGGPMTLQ RRVQPRVNVS PSKKGPLQHH NLLVCHVTDF YPGSIQVRWF LNGQEETAGV VSTNLIRNGD WTFQILVMLE MTPQQGDVYT CQVEHTSLDS PVTVEWKAQS DSARSK; Positive Samples: Mouse spleen, Rat thymus; Cellular Location: Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DPB1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.94 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: HLA-DPB1
• Gene Accession No.: P04440
• Gene Alias: beta1 domain MHC class II HLA DPB, CD, CELIAC1, class II HLA beta chain, DC-1 alpha chain, DC-alpha, DPB1, DQ-A1, GSE, histocompatibility antigen HLA-DR alpha, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, HLA class II histocompatibility antigen, DQ alpha 1 chain, HLA class II histocompatibility antigen, DQ(W3) alpha chain, HLA class II histocompatibility antigen, DR alpha chain, HLA DP14-beta chain, HLA-DCA, HLA-DP, HLA-DP histocompatibility type, beta-1 subunit, HLA-DP1B, HLA-DPB, HLA-DPB1, HLA-DQA, HLA-DQA1, HLA-DRA, HLA-DRA1, leucocyte antigen DQA1, leukocyte antigen alpha chain, major histocompatibility complex class II antigen beta chain, major histocompatibility complex, class II, DP beta 1, major histocompatibility complex, class II, DQ alpha 1, major histocompatibility complex, class II, DR alpha, MHC cell surface glycoprotein, MHC cla, MHC class II antigen, MHC class II antigen beta chain, MHC class II antigen DP beta 1 chain, MHC class II antigen DPB1, MHC class II antigen DPbeta1, MHC class II antigen DRA, MHC class II DQA1, MHC class II HLA-D alpha glycoprotein, MHC class II HLA-DP-beta-1, MHC class II HLA-DQ-alpha-1, MHC class II HLA-DRB1, MHC class II surface glycoprotein, MHC HLA DPB1, MHC HLA-DQ alpha, MLRW
• Gene Symbols: HLA-DPB1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-225 of human HLA-DPB1 (NP_0021123)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3115
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG