Invitrogen™ HLA-DR/DP/DQ Monoclonal Antibody (7.5.10.1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135414

Catalog No. 01-671-469

Description

The antibody reacts with a monomorphic determinant on MHC class II, HLA-D region molecules. It detects the molecules of the HLA-DR, DP and DQ loci. It inhibits the mixed lymphocyte culture. It also reacts with MHC class II molecules of various animals and is a useful tool for studies with dogs. The antibody is useful for the identification of HLA-D positive molecules using either microcytotoxicity testing or immunofluorescence/immunoperoxidase procedures. Furthermore, it was found useful for studies on functional aspects of MHC class II molecules.

MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DR/DP/DQ
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: P01903, P01911, P01920, P04440, P13762, P79483, Q30154
• Gene Symbols: HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
• Immunogen: Human EVB-transformed B-cell line DR3/3.
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Multi-species
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Cytotoxicity Assay, Immunocytochemistry
• Clone: 7.5.10.1
• Conjugate: Unconjugated
• Gene: HLA-DRB5
• Gene Alias: beta1 domain MHC class II HLA DPB; CELIAC1; class II HLA beta chain; Clone P2-beta-3; DLA class II histocompatibility antigen, DR-1 beta chain; DLA DRBB1 beta chain; DLA-DR beta; DLA-DRB1; DLA-DRBB1; DPB1; DR-16; DRB; DRB1; DRBB1; DRw10; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II antigen; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-15 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA DP14-beta chain; HLA-D; HLA-DP; HLA-DP histocompatibility type, beta-1 subunit; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQ; HLA-DQB; HLA-DQB1; HLA-DR; HLA-DR1B; HLA-DRB; HLA-DRB1; HLA-DRB2; human leucocyte antigen DRB1; IDDM1; integral membrane glycoprotein; LA-DRB; lymphocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex class II antigen beta chain; major histocompatibility complex, class II, DP beta 1; major histocompatibility complex, class II, DQ beta 1; major histocompatibility complex, class II, DR beta 1; MHC Class 2; MHC class II; MHC class II antigen; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II antigen DQB1; MHC class II antigen DRB1*15; MHC class II antigen DRB1*16; MHC class II antigen DRB1*3; MHC class II antigen HLA-DQ-beta-1; MHC class II DLA DRB1 beta chain; MHC class II DLA-DRB; MHC class II DLA-DR-beta-1; MHC class II DQ beta chain; MHC class II DR beta 1; MHC class II HLA-DP-beta-1; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DRB1; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC DLA-DR-beta-1 precursor; MHC DQ beta; MHC HLA DPB1; MHC HLA-D; MHC II HLA; SS1; XXbac-BPG161M6.1
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3115, 3119, 3122, 3123, 3125, 3126, 3127
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov