Invitrogen™ HLA-DRB3 Polyclonal Antibody

Catalog No.	Quantity
PIPA5120161	100 μL

Catalog No. PIPA5120161 Supplier Invitrogen™ Supplier No. PA5120161

Description

Rabbit Polyclonal Antibody

Positive test controls include: Raji, Mouse liver, Rat liver. The target is usually found in the following locations: Cell membrane, Endoplasmic reticulum membrane, Endosome membrane, Golgi apparatus, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein, trans-Golgi network membrane. Immunogen sequence: GDTRPRFLEL RKSECHFFNG TERVRYLDRY FHNQEEFLRF DSDVGEYRAV TELGRPVAES WNSQKDLLEQ KRGRVDNYCR HNYGVGESFT VQRRVHPQVT VYPAKTQPLQ HHNLLVCSVS GFYPGSIEVR WFRNGQEEKA GVVSTGLIQN GDWTFQTLVM LETVPRSGEV YTCQVEHPSV TSALTVEWRA RSESAQSK.

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain ( beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DRB3
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.12 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: HLA-DRB3
• Gene Accession No.: P79483
• Gene Alias: DR7; DRB1; DRw10; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA DR3B; HLA-DR1B; HLA-DR3B; HLA-DRB; HLA-DRB3; human leucocyte antigen DRB3; major histocompatibility complex, class II, DR beta 3; MGC117330; MHC Class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II HLA-DR beta 3 chain; SS1
• Gene Symbols: HLA-DRB3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-227 of human HLA-DRB3 (NP_072049.2).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3125
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov