HLA-DRw52 Monoclonal Antibody (7.3.19.1), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA135422

Catalog No. 01-671-477

Description

HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DRw52
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: P01911
• Gene Symbols: HLA-DRB1
• Immunogen: HLA DRw52.
• Regulatory Status: RUO
• Gene ID (Entrez): 3123
• Content And Storage: 4° C
• Form: Liquid

• Applications: Cytotoxicity Assay, Immunocytochemistry
• Clone: 7.3.19.1
• Conjugate: Unconjugated
• Gene: HLA-DRB1
• Gene Alias: Clone P2-beta-3; DR-16; DRB1; DRw10; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-15 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA-DR1B; HLA-DRB; HLA-DRB1; HLA-DRB2; human leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II antigen; MHC class II antigen DRB1*15; MHC class II antigen DRB1*16; MHC class II antigen DRB1*3; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; SS1; XXbac-BPG161M6.1
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov