Invitrogen™ HLA-DRw52 Monoclonal Antibody (7.3.19.1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135422

Catalog No. 01-671-477

Description

The antibody reacts with a polymorphic determinant on HLA-DR molecules which is associated with DR3, DR5, and DRw6 (DRw52-like). It does not react with DRw8. The antibody reacts with part of the HLA-D molecules (29+34 kD). The determinant is strongly expressed on DR3 positive cells and more weakly on DR5 and DRw6 positive cells. The antibody is useful for HLA-DR typing and biochemical characterization of the DR52w positive molecules and functional studies. Cross reacts with Chimpanzee, Macaca-apes and gorilla.

HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Specifications

• Antigen: HLA-DRw52
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene Accession No.: P01911
• Gene Symbols: HLA-DRB1
• Immunogen: Human HLA-DRw52.
• Regulatory Status: RUO
• Gene ID (Entrez): 3123
• Content And Storage: 4°C
• Form: Liquid

• Applications: Cytotoxicity Assay, Immunocytochemistry
• Clone: 7.3.19.1
• Conjugate: Unconjugated
• Gene: HLA-DRB1
• Gene Alias: Clone P2-beta-3; DR-16; DRB1; DRw10; DW2.2/DR2.2; FLJ75017; FLJ76359; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1-15 beta chain; HLA class II histocompatibility antigen, DRB1-16 beta chain; HLA class II histocompatibility antigen, DRB1-3 chain; HLA-DR1B; HLA-DRB; HLA-DRB1; HLA-DRB2; human leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1; MHC class II antigen; MHC class II antigen DRB1*15; MHC class II antigen DRB1*16; MHC class II antigen DRB1*3; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; SS1; XXbac-BPG161M6.1
• Host Species: Mouse
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

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