Invitrogen™ HMGCR Recombinant Rabbit Monoclonal Antibody (6Y9L8)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535242

Catalog No. PIMA535242

Description

Immunogen sequence: IKPLVAETDT PNRATFVVGN SSLLDTSSVL VTQEPEIELP REPRPNEECL QILGNAEKGA KFLSDAEIIQ LVNAKHIPAY KLETLMETHE RGVSIRRQLL S.

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

Specifications

• Antigen: HMGCR
• Classification: Recombinant Monoclonal
• Concentration: 0.3 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P04035, P51639, Q01237
• Gene Symbols: HMGCR
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HMGCR (P04035).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 6Y9L8
• Conjugate: Unconjugated
• Gene: HMGCR
• Gene Alias: 3H3M; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; HMG-CoAR; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3; MGC103269; Red
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15357, 25675, 3156
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov